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Associations between US features, knee pain, radiographic change and clinical signs of inflammation could then be explored. Secondary objectives were to determine if US features change in tandem with fluctuations in knee pain (1) over time and (2) with improved pain following a therapeutic intervention in people with SOA.Methods. In a cross sectional multiple group comparison study, 243 participants were divided into 4 groups based on the presence of absence of knee pain and ROA.

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