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He was later awarded a Wellcome Trust Research Leave Fellowship to establish an independent research programme at Sheffield where his work has focussed on the molecular basis of cyst formation, drug discovery and translational medicine in ADPKD. He was the main clinical expert to the NICE appraisal panel for the use of Tolvaptan in ADPKD and chaired the Renal Association Working Group which developed the first clinical guidance for its adoption and use in the UK. We have defined the critical molecular interactions necessary for the formation, trafficking, regulation and function of the polycystin 1/polycystin 2 ADPKD protein complex and have identified several key changes in cell function and signalling resulting from the disease phenotype.
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